Synaptic vesicle fusion: A biophysics perspective
Lunedì 16 ottobre p.v. alle ore 15.30 il Prof. Yeon-Kyun Shin, Professore di Biofisica alla Iowa State University, terrà un seminario dal titolo “Synaptic vesicle fusion: A biophysics perspective” al Polo Didattico e Scientifico Vallisneri in Aula Magna, in collaborazione con la Scuola Galileiana.
Vesicle fusion is required for neurotransmitter release at the synapse. Membrane fusion is mediated by the protein nanomachine composed of SNAREs, Ca2+-sensor synaptotagmin, and other auxiliary proteins. EPR and single molecule techniques are used to investigate the structure and the function of SNAREs and regulatory proteins. In particular, research is focused on identifying the major intermediates on the membrane fusion pathway and in reproducing millisecod membrane fusion, a feature unique to synaptic vesicle fusion. I will discuss the current status of our understanding of synaptic membrane fusion with a biophysics perspective.